ANNUAL REPORT

icmr logo

2011

(October 2010 to September 2011)



 

Introduction to the New Institute  & inauguration

 

Development of Laboratory for Clinical & Research work

  Land Allotment for Main Institutional Building at Bhouri, Bhopal
1. Allotment of Land
2. Construction of State of Art Institute

 

Human Resource

 

Constitution of Committees

 

Highlights of ongoing research activities

 

New Research Project Proposals

 

Awareness activities

 

Other Activities

 

Budget

 

Annexure


letter


DEDICATION

The first Annual Report of National Institute for Research in Environmental Health (Indian Council of Medical Research), Bhopal is dedicated to those who lost their lives in Bhopal Gas Disaster 2/3rd December 1984.



 PREFACE

The genesis of ICMR’s 31 permanent Institute, National Institute for Research in Environmental Health (NIREH) is mainly to address the issues pertaining to immediate and long term needs of those who were affected from the Bhopal disaster which happened on 2nd & 3rd December 1984.  The dedicated Institute will strive to alleviate the suffering of the humanity through its all-round efforts viz., through translational research activities to make the life more meaningful against all the odds which needs to be addressed in a long run.

          The details of the scientific work carried out by ICMR through trans-disciplinary multi-institutional scientific collaboration during 1985-94 have been brought out three technical reports pertaining to “Health Effects of the Toxic Gas Leak from the Union Carbide Methyl IsoCynate Plant Bhopal” on different aspects  Epidemiological, Clinical and Toxicology & Pathology.  These  pertain to major ICMR Research Projects undertaken during the period 1985-94 and are in the nature of compilation of all the relevant information, including publications and relevant bibliography. 

The details were also brought out in special supplement of Indian Journal of Medical Research (IJMR)in 1987 and also  on the article published in  “Current science” (Vol.86, No7, 10th April 2004 PP 905920) and other two technical reports which elaborate comprehensive picture.

The NIREH  institute was    inaugurated on 11th October 2010 has ambitious  plans of addressing the concerned issues in the form of immediate needs, short term needs and also the long term preparedness to address not only pertaining to this issue but also to have preparedness to address the issues of wider dimensions at the national level.  The details can be referred through the reports of the Empowered Committee, Task Force Committee, and Scientific Advisory Committee which are actively participating in bringing up the new establishment.  The report for the year 2011 for the period from October 2010 to September 2011 is a milestone in this direction with its humble efforts.

The staff of NIREH are indebted to the constant guidance, support and advise being extended by Dr.V.M.Katoch, Secretary, Department of Health Research & Director General, Indian Council of Medical Research, Shri Sanjiv Dutta, Financial Advisor, ICMR, Shri Arun Baroka, Sr. Deputy Director General (Admn.), ICMR, Dr. Bela Shah, Head, Division of Non Communicable Diseases ICMR; Government of Madhya Pradesh, Ministry of Health & Family Welfare and other Ministries concerned particularly Dr. K.K.Dubey, Director, Kamla Nehru Hospital and Deputy Secretary, Department of Health & Family Welfare, Government of Madhya Pradesh,   Chairman and Members of various Committees who are instrumental in initiating all possible measures in bringing  up this Institute.

 

Dr. N. Banerjee



INTROUCTION TO THE NEW INSTITUTE        Goto Top

Recently, after the judgment of Sessions Court, Bhopal on 7th June 2010, Government of India, in the first half of June, 2010, set up a   Group of Ministers (GoM) to examine all the issues related to Bhopal Gas Leak Disaster. The Union Cabinet had passed a resolution on 24th June, 2010 directing, interalia,   ICMR to establish a new permanent   research centre at Bhopal. The ICMR set up its 31st permanent Research centre “National Institute for Research in Environmental Health” at Bhopal, on 11th October, 2010.  Even though the immediate goal of this Institute is for health research on people affected by exposure to MIC, and to study the health effects due to alleged pollution of soil and water because of debris left by the Union Carbide Factory after the tragedy of 1984, the long term goals of the Institute shall be to focus on the entire issues of environmental health. The Institute would be focusing on research on several issues of gas-exposed victims particularly respiratory and eye related diseases, kidney diseases, cancer, genetic disorders, congenital disorders, mental and neurological health, women related medical issues and second generation children related medical issues and rehabilitation. This Institute will eventually become a Centre of Excellence to improve environmental health research and play a leading role in tackling environmental health issues. Ultimately, this Institute aims at emerging as an apex research institution on environmental health in India. 

Inauguration of the new permanent Institute “National Institute for Research in Environmental Health” (NIREH) was done on 11th October 2010 at 4.00 p.m. by Mr. Babulal Gaur, Hon’ble Minister, Government of Madhya Pradesh, Department of Bhopal Gas Tragedy Relief and Rehabilitation & Local Self Government and Mrs. Krishna Gaur, Mayor, Bhopal Municipal Corporation, Bhopal and Dr.V.M. Katoch, Secretary to Government of India, Department of Health Research and Director General, Indian Council of Medical Research, (ICMR),  New Delhi.

The function was attended by Ms. Shalini Prasad, Joint Secretary, to Government of India, Department of Health Research, New Delhi,  Mr. Sanjiv Dutta, Financial Advisor, ICMR, New Delhi,  Mr. Arun Baroka, Senior Deputy Director General (Admn),  ICMR, New Delhi,  Dr. Bela Shah, Scientist ‘G’  & Head (Non Communicable Division), ICMR,  New Delhi, Dr. N. K. Mehra, Professor, Department of Transplant Immunology & Immunogenetics, All India Institute of Medical Sciences, New Delhi, , Dr. P.M. Bhargava, Former Director, Centre for Cellular and Molecular Biology, Hyderabad, Dr. V.K. Vijayan, Former Director, V.P. Chest Institute, Dr Neeru singh Director, RMRCT, ICMR & Head  (ECD) , Dr. H.R. Rajmohan, Officer In charge, Regional Occupational Health Centre, National Institute of Occupational Health, Bangalore, Dr. Lalit Kant, Former Scientist, ICMR, Dr R C Sharma, Ex Director-in-Charge, DMRC, ICMR , Dr. D.K. Shukla,  Scientist ‘F’, (Non Communicable Division), ICMR, New Delhi.
Dr. J.T. Ekka, Commissioner, Gas Relief and Rehabilitation, Government of Madhya Pradesh, Bhopal, ,  Dr. K.K. Dubey, Director, Kamla Nehru Hospital, Bhopal, Mr. K.K.Katiya, Deputy Secretary, Government of Madhya Pradesh, Bhopal Gas Tragedy Relief and Rehabilitation, Bhopal, Dr. R.S. Verma, Chief Medical Officer, Gas Relief, Bhopal, Dr. S.K. Mathur, Superintendent, Kamla Nehru Hospital, Bhopal, many Doctors from Gas Relief Department and all staff of Centre for Rehabilitation Studies were also present on the occasion.

Representatives of local Non Governmental Organizations like Mr. Satinath Sarangi, Mrs. Rachna Dhingra, Shri Abdul Jabbar, Mrs. Sadhna Karnik and Mr. Alok Pratap Singh, Mrs. Rasheeda Bee have also attended the programme.

Many other distinguished guests were also present on that day.

Inauguration of the new Institute was done in the same place where Centre for Rehabilitation Studies has been functioning under Bhopal Gas Tragedy Relief and Rehabilitation Department of Government of Madhya Pradesh which has been allotted to ICMR. 

The immediate goal of this Institute is health research on people affected by exposure to MIC (1984).

Before the inauguration, ICMR had already taken very important steps to take up the challenge through building of a strong platform.  The following committees were constituted to understand multi-directional need to carry out the task smoothly.

The ICMR along with Government of Madhya Pradesh has initiated the process of establishing NIREH.   During last one year the following activities have been carried out to achieve the part of goal.

  1. Renovation of allotted space at Kamla Nehru Hospital, Gas Relief Department to develop epidemiological unit and laboratory unit.
  2. Procurement of land from Government of Madhya Pradesh for development of main building of NIREH.
  3. Procurement of Equipment and other accessories immediately to start the laboratories.
  4. Appointment of Staff.
  5. Concept of various functional units at NIREH, Kamla Nehru Hospital building, Bhopal.
  6. Vision Document of NIREH.
  7. XII five year plan
  8. Standing Finance Committee document

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DG’s arrival for Inauguration of NIREH on 11th October 2011

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Inauguration of NIREH on 11th October 2011

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Inauguration of NIREH on 11th October 2011

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Inauguration of NIREH on 11th October 2011

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DG with other dignitaries after Inauguration of NIREH

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 Inauguration by lighting of traditional lamp

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Guests and other dignitaries during the inauguration

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DG addressing press after Inauguration of NIREH



DEVELOPMENT OF LABORATORY FOR CLINICAL & RESEARCH WORK Goto Top

1.       CIVIL WORK FOR RENOVATION OF THE ALLOTTED SPACE, KAMLA NEHRU HOSPITAL, GAS RELIEF DEPARTMENT, BHOPAL

          The Government of Madhya Pradesh allotted fist floor of Kamla Nehru Hospital Building Annex where the Centre for Rehabilitation Studies- Research wing of Government of Madhya Pradesh was functioning, for development of Clinical & Therapeutic Division of NIREH which is approximately having an area of 1036 sq mtr.   It has been divided in two wings for civil construction.  The Right Wing is for Laboratory wing and Left wing office area and non clinical work.
Subsequently it was decided to increase the area and add another floor for accommodating field staff, sterilization, record room, library, canteen and some area left for future expansion.

The Capital Project Administration (CPA), a civil construction wing under Department of Housing and Environment, Government of Madhya Pradesh was contacted and asked to submit detail proposal regarding renovation of the Centre for Rehabilitation Studies.

To carry out the renovation work of the Laboratory, Clinics and Epidemiological section in the allotted area within Kamla Nehru Hospital building.  Administrative and financial approval was given.  Purchase order of equipments was made through Institute of pathology under the supervision of equipment committee of ICMR. 

As the newly allotted area in Kamla Nehru Hospital was subjected for renovation so it was decided to shift the office of NIREH to another floor of Kamla Nehru Hospital (5th floor).

 

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First Floor Layout plan of  NIREH Laboratory at Kamla Nehru Hospital Building Annex
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Furniture Layout plan of  NIREH Laboratory at Kamla Nehru Hospital Building Annex
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Clinical Wing plan of NIREH Laboratory at Kamla Nehru Hospital Building Annex

DESIGN             

Planning, Designing has been done by the Capital Project Administration (CPA) along with their architect EPCO in consultation with Head, NIREH  as per the requirement and suggestion by ICMR. In this regard presentation on proposed design was made at ICMR headquarters before the committee of senior officials and scientists. Accordingly a final design was made after incorporating necessary changes / suggestion from ICMR.

MATERIAL APPLICATION

Office wing has capacity of about Ninety staff members, Clinical wing has Eight consultant chamber and Eight laboratories (PFT LAB, MICROBIOLOGY LAB, CENTRAL EUIPMENT LAB, DNA LAB , PATOLOGY LAB, HAMEOTOLOGY LAB, OPTHALMOLOGY LAB).

  • The provision of fiber cement board and galvalume section partition for making the area fire retardant.
  • Double Layer Gypsum board false ceiling have been used for better insulation and fire safety.
  • The entire surface has been laminated to make the vertical surfaces maintenance free at clinical area.
  • Separate sterile area is being provided in few laboratories
  • Antimicrobial lining on wall is being provided for germ free seamless surface.
  • Satin finish anti skid flooring ( vitrified tile ) have been used as corridor and office,
  • Hi gloss RAK make vitrified tiles have  been used inside the laboratories
  • Energy efficient AC Machine VRF System with 8 stage Air purifier at laboratories and clinical area.
  • Vertical Air flow / suction in laboratories are from the bottom and through air purifiers to prevent infection.
  • Laboratory (8 –nos) work surface is factory made steel furniture.
  • X-RAY room / lab confirming to AERC norms
  • Separate reagent storing system with ventilation has been incorporated.
  • Compact storage system ( fire retardant )  at both floors
  • Ergonomic Modular furniture, chairs is being provided
  • Provision of Fire detection system, Closed circuit surveillance, LAN networking, access control / time attendance register, EPABX and Communication have been incorporated.
  • Provision of Electrical DB and Internal wiring, lighting fixture, , Bus bar panel, DG and PF panel,
  • Provision of DG-50 KVA- 3 Phase Cummins, Fire Hydrant System.

2.        DEVELOPMENT OF LABORATORIES

NIREH has started taking its shape and accelerated towards the attainment of perfection on the grounds of research and establishment of state of the art laboratories at the Institute.

In last one year emphasis have been made on the development of research laboratories.   These research laboratories will be engaged in the frontline research at the frontiers of modern biology and applied science. These laboratories encompass majorly seven departments with one central laboratory.   Each department will have state of the art facilities for the dissemination of the overall concept in their respective field of research.

LABOROTORY DIVISIONS:

  • Epidemiology Division, which will look forward in the areas of public health, Biostatistics, Sociology, Rapid response and Bioinformatics.
  • Molecular Biology Division, will have its role in the areas of Genomics, Proteomics, Immunology and cytogenetic.
  • Pathology Division, assist clinical division of the Institute providing all available pathological investigations.
  • Microbiology Divison, will conduct research on basic biology of microbiology pathogens(bacteria, viruses, fungi) by utilising the tools of cell biology, molecular biology and immunology.
  • Biochemistry Division, will have an objective of advancement of knowledge in the fields of biological chemistry.
  • Clinical and Therapeutical Division, all the clinical activities will be carried out under this Division where project-wise examination of patients will be carried to establish the diagnosis.
  • Central laboratory, will be equipped with all major state of art high class Equipment.  This laboratory will be shared by all other laboratories where common investigations are to be carried out.

Therefore, in an endeavour to establish these top quality laboratories, Institute has installed various instruments which have been directly purchased through Indian Institute of Pathology, Delhi.

To impart knowledge of recent advancement in the field of science and technology, up gradation of laboratories at NIREH will be the prime motive.

EQUIPMENTS

The Division wise list of equipments purchased/ installed/ immediately required at the Institute as per the recommendation of Equipment Committee.

The List of Equipment is at Annexure III.

FUTURE UTILITY OF THE LABORATORY

The chemical disaster usually involves large scale leakage of gas (es), solvent vapours, aerosols, microorganisms and spillage of oil or chemicals. A wide spread exposure of human population would be expected following chemical disasters / accidents which would include persons living near and away from the site, the workers living near the site (industry), emergency rescue workers  (fire men, laboratory workers and workers collecting samples). The exposure would be acute in large concentrations at the time of accident and subsequently long term exposure in small quantities from the contaminants settled at the site, vegetation, utilities like HAVC, heating units and interiors of the houses, and on the water bodies in the vicinity. The population exposed would also include vulnerable persons such as elderly, pregnant ladies, and growing children.

In view of the above the laboratory set up should have equipments and capabilities for detection of gases, chemicals, chemical mixtures and their possible metabolites in the environment and human tissues as well as blood, urine and hair of the exposed individuals. Besides, the analytical capabilities, the laboratory should have complete set up for the morphological and pathological studies from light microscopy up to the level of electron microscopy. Set up for immediate assessment of genotoxic potential as well as impact on reproductive -, immune -, and nervous systems for assessment of outcome of the exposure to chemicals & unknown chemicals or chemical mixtures would also be required. Following the chemical disaster it would be necessary to estimate the suspected chemicals in urine and other biological samples of humans to assess exposure and, hematological and enzyme profile to assess the impact on health, Further it would be necessary to carry out detailed experimental studies by exposing appropriate animals through inhalation and other likely routes of exposure. Hence, a complete set up of inhalation facility along with simultaneous measurement of chemical residues, possible metabolites should be established.



LAND ALLOTMENT FOR MAIN INSTITUTIONAL BUILDING AT BHOURI, BHOPAL         Goto Top

1.       ALLOTMENT OF LAND

The Director General, ICMR and senior officials from ICMR have visited Bhopal in the month of January 2011 and approved the land at Bhouri and the same was communicated to Government of Madhya Pradesh for allotment.  It is expected the allotment will come during October 2011.

2.       CONSTRUCTION OF STATE OF ART INSTITUTE:

After allotment of land the following issues have to be taken up.

Building Advisory Committee constituted by DG, ICMR has taken up the initiatives of architectural plan, selection of the executing agency and evaluation.  The committee will guide and monitor the progress.



EXISTING STAFF        Goto Top

1.       ICMR HAS TAKEN OVER OF CENTRE FOR REHABILITATION STUDIES (GOVERNMENT OF MADHYA PRADESH)

The GoM directed ICMR that “the staff of the existing Centre for Rehabilitation Studies, to the extent they are qualified, should be taken over by ICMR” and ICMR had taken over  and appointed all the staff of  Centre for Rehabilitation Studies accordingly in National Institute for Research in Environmental Health (ICMR) on 1st February 2011.  The appointment has been made on contractual basis till the creation and approval of the posts for the Institute.  After that all the staff will be adjusted/ accommodated against new created posts. 

The list of staff taken over by ICMR in project mode is at Annexure II.

2.         APPOINTMENT OF LABORATORY STAFF:

            In the new Institute there is a proposal of establishment of different scientific laboratories like Molecular Laboratory, Biochemistry Laboratory, Pathology Laboratory etc.  As there was no trained staff in NIREH, ICMR appointed the following staff to monitor all the activities related to upcoming laboratories.

  • Dr. Farida Khan,  Scientific Consultant
  • Mrs. Sneha Chakravarty, Senior Research Fellow. 

3.       ENGAGEMENT OF SCIENTIFIC CONSULTANTS:

In addition to the above mentioned Laboratory staff, ICMR engaged five Scientific Consultants for providing guidance regarding new scientific research proposals, to carry out new research studies with the help of present staff of NIREH and to provide support to the patient care services undertaken by the Institute.  It was suggested to initiate research work on the following areas:

  • Respiratory diseases
  • Eye-related diseases
  • Cancer
  • Total Renal Failure
  • Genetic disorders
  • Congenital disorders
  • Women-related medical issues
  • Second-generation children related medical issues

The six consultants mentioned below are currently working on strategies and to follow up the studies: The following consultants have joined NIREH on 2nd May, 2011.

  • Dr. R.C. Sharma, MBBS, MD, Former Director, Desert Medicine Research Centre, Jodhpur.
  • Prof. R.S. Murthy, MBBS, MD, Former Director, National Institute of Mental Health and Neurosciences, Bangalore.
  • Prof. V.K. Bharadwaj,  MBBS, MD (Patho & BaCT), Professor of Pathology, Chirayu Medical College, Bhopal
  • Dr. B. Mishra,  MBBS, MD, Associate Professor, Chirayu Medical College, Bhopal.
  • Dr. Arun Bhatnagar, M.B.B.S, M.S, MCh,  Associate Professor, Department of Plastic Surgery, Gandhi Medical College, Bhopal
  • Dr. R.K. Gupta, MBBS, DOMS  Senior Consultant Ophthalmology, Bhopal

The scientific consultants and senior research fellows are currently taking care of the laboratory, infrastructure developmental activities.



CONSTITUTION OF COMMITTEES        Goto Top

The primary objective of the Institute is to undertake research on the continuing health needs of gas exposed population and to undertake health system research, to build capacity for research, to develop human resources etc.  There was a need of experts scientists from different field of expertise for better planning and execution, Secretary, Department of Health Research, Ministry of Health and Family Welfare, Government of India & Director General, ICMR constituted different committees.  (Annexure-I)



RESEARCH PROGRESS REPORT        Goto Top
(October 2010 to September 2011)

1.       Population Based Long Term Epidemiological Studies on the Health Effects of Toxic Gas Exposure

Investigator:          Dr. N. Banerjee,  Head, NIREH, Bhopal

Co investigator:    Dr. Sushil Singh, Research Officer, NIREH, Bhopal
Mrs. Moina Sharma, Assistant Research Officer (Stat) NIREH, Bhopal.

The long term epidemiological studies was initiated in the year 1985 by ICMR through Bhopal Gas Disaster Research Centre at Gandhi Medical College, Bhopal.  These studies were completed in the year 1994.  ICMR has brought out the Technical Report for the period 1985-1994.

The study was continued under Gas Relief Department of Government of Madhya Pradesh and results were presented in the meeting of Advisory Committee constituted by Hon’ble Supreme Court of India.  It was recommended by the Chairman, Advisory Committee to prepare the 2nd Technical Report on Long Term Epidemiological Studies (1985-2005) should be prepared in the similar pattern as 1st Technical Report.

The Technical report was prepared by the Centre for Rehabilitation Studies, Gas Relief Department, Bhopal and the reports was reviewed twice by National Institute of Medical Statistics, ICMR, New Delhi and final draft was prepared and reviewed by Dr. B. Mishra, Consultant Epidemiology, NIREH and now the report is submitted to Director General, ICMR for approval.

Under the Long Term Epidemiological Study a cohort of  80021 population in the exposed population and 15931 population in the control area was for the study purpose. 

Objectives:

    • To study the socio-economic and demographic changes in the control population through six monthly surveys.
    • To study the vital events like births and deaths.
    • To study the point prevalence and period prevalence morbidities.
    • To follow up the chronically ill patient in cohort’s population.

After NIREH came into existence the following tasks were taken:

Morbidity Survey

The 44th round of six monthly detailed survey was in progress.  The survey continued till August 2011.  The cohort population under surveillance continues to show high morbidities in respiratory, ophthalmic and gastro-intestinal tract systems in relation to the intensity of exposure in the affected area compared to the control population.

Updation of  Cohort

It was noticed during the six monthly  surveys that the loss of families was increasing drastically due to various reasons viz migration, no response, missing.  In which migration of families was the biggest contributing factor.  So in order to trace migration to the best possible extent the task of updation of cohort was taken up.  Simultaneously information on other parameters was also updated. This task was taken up in the month of November 2010 and continued till June 2011.

Survey on Chronically ill patients

A task on identifying chronically ill patients was taken up during the period of March 2011 to July 2011.  In the total exposed area 2242 and 560 chronically ill patients were identified b the Research Assistant.  The task of getting these chronically ill patients clinically diagnosed is being carried out.

Death Records

Along with the 44th six monthly survey a task of collecting number of deaths,  cause of death from 1985 to 2011 was also carried out.  This was done as to authenticate and strengthen the already existing data on deaths. 

Birth Records

Detailed information on termination of pregnancy records was also collected during this period.

Modification of present methodology

Since the 44th record of six monthly survey, chronically ill patients survey, death records, birth records is over and now under the guidance of Dr. Brajendra Mishra, Consultant, the epidemiological study has been modified.  Now onwards all the patients identified by the Research Assistants will be subjected to total clinical evaluation through community health clinics to be established in four different hospitals of Gas Relief Department.  Based on this modification of the study necessary epidemiological and clinical training will be provided in the month of October to the field staff with the help of scientific Consultants of NIREH. 

2.       Training programmes of Research Assistants and Assistant Research Officers of the Institute

Dr. R.S. Murthy, Professor of Psychiatry (Retd.) NIMHANS, Bangalore visited Bhopal to develop Psychiatric study.  He organized meeting with Dr. Chhabra, Consultant Psychiatry, Kamla Nehru Hospital on 5.9.11.  Dr. Murthy had also meeting Scientific Staff of NIREH to discuss cohort and epidemiological study.  He also addressed all the staff of NIREH.  He discussed about the knowledge of psychiatric problem along the registered cohort population.  After detail discussion Dr.Murthy has organized training programme for Research Assistants and Assistants Research Officer of the Institute.

A small pilot project was designed by Dr. Murthy.  Collection of Psychiatric data has been carried out with the help of epidemiological staff of the Institute.  In future based on available old data and present data a detailed study proposal will be prepared. 

3.        Eye Camp

          It was planned to organize eye camp by Scientific Consultant to understand Ophthalmic problem among the gas victims till the development of Clinic at the Institute. 

The first Eye camp was organized in mildly affected area of ICMR cohort on 07-09-2011 from 9 a.m. to 1.00 p.m.  This eye camp was organized at Community Health Centre (Lady Bhore Hospital) of National Institute of Research in Environmental Health, ICMR.

          In camp, 23 patients having different ocular morbidities were examined and out of this 10 cases were of cataract.  All these patients were referred to Kamla Nehru Hospital, Bhopal for further treatment.

4.       Congenital Malformation Cell in Gas Relief Department

NIREH, Bhopal has been providing necessary scientific input in preparation of Congenital Malformation Cell in Indira Gandhi Hospital under Gas Relief Department, Government of Madhya Pradesh. 



NEW RESEARCH PROPOSALS        Goto Top

The following research proposals have been prepared with the help of Scientific Consultants and sent to ICMR for review.

1.       Title of the project:An Analysis of existing congenital malformations among the urban and rural population of Bhopal including the off springs of gas affected population”

Investigator:        Dr. Arun Bhatnagar, Consultant, NIREH, Bhopal

Co investigator:   Dr. Nalok Banerjee, Head, NIREH, Bhopal
Dr. Brijendra Mishra, Consultant, NIREH, Bhopal
Introduction
Congenital malformations are single or multiple defects present in a baby at birth, in a malformation, the development of a structure is arrested, delayed, or misdirected early in embryonic life and the effect is permanent.
Genesis of congenital malformations is multifactorial combining genetic predisposition with environmental factors including prenatal also i.e. toxic exposure of the fetus (for example, to alcohol etc.), birth injury, nutritional deficiencies, anoxia, radiations and, in many cases, maternal stress combining  nutritional deficiency( i.e folic acid ) or intake of teratogenic drugs, virus or chemicals .

All parents are at risk of having a baby with a birth defect, regardless of age, race, socioeconomic status and geographic location .They can involve any organ or system singularly or in combination (Syndromes). In US (and many other developed countries) 2-3% of babies are born with a major congenital malformation and they are now the leading cause of infant mortality there. They are present in one of every three babies that die in the US. In an effort to address the emerging importance of Birth defects, the WHO Assembly on May 21, 2010 adopted a resolution calling all Member States to promote primary prevention and the children with birth defects by: developing and strengthening registration and surveillance systems; developing expertise; strengthening research and studies on etiology, diagnosis and prevention; and promoting international cooperation. A training program is being offered to provide the necessary set of skills and tools.

Link to WHA resolution: p.63 http://apps.who.int /gb/ebwha/pdf_files /WHA63-REC1/WHA63_REC1-P2-en.pdf)
 
In India with multireligion and multiethnic population not much data is available on congenital malformations. In India current perinatal mortality rate significantly quite higher than developed countries and is attributed mostly to the prematurity, infectious diseases, malnutrition , birth trauma and low birth weight .Data in India doesn’t still enlist the genetic diseases or malformations as cause of higher  neonatal or perinatal mortality rate or stillbirths.

Congenital malformations are major cause of death of neonates in India where prenatal detection and treatment are not adequate in many hospitals and places .Incidence is higher in still births. Main causes of much congenital malformation are genetic, and hence early detection and their prevention would make the small healthy family motto a success. Keeping this in mind present project has been designed.  “An Analyses of existing congenital malformations among the population of BHOPAL including the off springs of gas affected population”.

The major aims and objective are

  1. To analyze and establish the pattern of the congenital malformations among the urban and rural population of Bhopal division including both gas affected and non affected areas and classify their prevalence as major and minor .
  2. To establish the correlation of malformations with the age of parity, marriage in consanguinity and socioeconomic status (nutrition & hygiene).
  3. To enlist and analyze any precipitating factor present in the environment during early trimester of pregnancy.
  4. A  Booklet / Brochure for the early detection of congenital malformations with pictorial illustrations ,salient features and scoring system will  be distributed to  primary health care personnel  (Asha / Anganwadi) having guidelines for detection of malformations which need immediate medical or  surgical  help.

Project will also have service component .The identified cases will be subjected to required  investigations including genetic, biochemical, radiological and other relevant specific ones to establish the complete diagnosis of the various malformations in consultation with experts including Pediatric ,cardiac, neuro, plastic and orthopedic surgeons . Genetic counseling of both parents will be done and attempts would be made to diagnose the congenital malformations in utero through genetic, imaging and other screening techniques in subsequent pregnancies in identified families. On detection of such fetuses the parents would be counseled for taking appropriate legal measures permitted under the law.  As a service component of study Environmental rehabilitation will be suggested to the parents (planning for subsequent child) on the basis of identified  precipitating environmental risk factors. In the later stage of study a Hand Book will be prepared on  “Management Guidelines” for the prevention ,treatment and rehabilitation of various congenital malformations to be distributed to educate the parents of affected families through primary health care workers involved in the antenatal care and reproductive health. This study will contribute to the congenital malformation registry. A Reporting Performa” for congenital malformation registry, will be filled by Primary Health Care Worker ( Aanganwadies / Ashas)  reporting any predisposing factor if found also for any congenital malformation (live or still born) occurring in his or her territory. The expectant mothers would also be educated through them regarding  nutritious diet, avoidance of drugs, and to report about the infective disease if any encountered during the first trimester of pregnancy.

Material and Method 
All the cases of congenital malformation residing in Bhopal division including gas affected area and allegedly water contaminated area will be examined and screened for the establishment of provisional diagnoses as per Performa. History of consanguinity will be asked .Any exposure to environmental toxins, radiations, chemicals, fever or drug intake during first trimester of pregnancy will be asked. Screened out patients and parents will be submitted to the relevant investigations and genetic analyses and mapping .in consultation with the experts of that field. We shall be taking the help of expert specialist consultants of Gandhi Medical College and will be outsourcing for the any special investigations if required, moreover we shall be taking the help of cytogenetic lab and molecular biologist to finalize a protocol for the detection, management and prevention of the diagnosed congenital malformations. The project would have Service component referring the diagnosed congenitally malformed children to the respective Department of specialty or any other concerned higher centers in the state or outside for the medical / surgical treatment/ or  prostheses and or rehabilitation.

2.        Title of the project: “Congenital malformation Registry”

Investigator:-       Dr. Brajendra Mishra, Consultant, NIREH, Bhopal

Co investigator:   Dr. Nalok Banerjee, Head, NIREH, Bhopal
Dr. Arun Bhatnagar, Consultant, NIREH, Bhopal

This project would be run under the principal investigatorship of Dr. Brajendra Mishra and under Co-Investigatorship of  Dr. Nalok Banerjee and Dr. Arun Bhatnagar. The project would be supported by a board of advisors from the areas like Pediatrics, Pediatric surgery, Plastic Surgery, Obstetrics and Gynecology, Forensic Medicine, Anatomy, Community medicine/Epidemiology Sonology and imaging. Besides the faculties mentioned above other experts as pediatric Neuro/cardiovascular surgeons would be consulted/ inducted as and when required in the advisory board.  This project would be a long term continuous study done through active and passive surveillance. In US (and many other developed countries) 2-3% of babies are born with a major congenital malformation and they are now the leading cause of infant mortality there. They are present in one of every three babies that die in the US.

            The study would be conducted with the objectives of a) Epidemiological study and documentation of congenital malformation in Bhopal (Urban including gas affected cohort and their second generation children and / Rural and Hoshangabad division of Madhya Pradesh. the issue of congenital malformation would be examined in reference to the role of factors like infections, drugs, nutritional deficiencies, radiation and exposure to certain known occupational/environmental hazards and social customs like consanguinity etc in causation of  the congenital malformation. The expectant mothers would be educated through Aanganwadies/Ashas regarding healthy nutritious diet, avoidance of drugs, and to report about the infective disease encountered during the first trimester of pregnancy. In later stages of the study the attempts would be made to diagnose the congenital malformations in utero through genetic, imaging and other techniques. On detection of such fetuses the parents would be counseled for taking appropriate legal measures permitted under the law. The project would have Service component in form of referral of congenitally malformed children to Department of Pediatric Surgery/Plastic surgery and other higher centers for treatment/Surgical Treatment prosthetics and rehabilitation. The attempts would be done to provide these services to the patients either free of cost oat minimum cost to the parents.

3.   Title of the project: “Assessment of biochemical markers in patients with pulmonary disorders caused by MIC and other environmental factors”

Investigator:-       Dr.  Farida Khan, Consultant, NIREH, Bhopal

Co investigator:   Dr. Puneet Gandhi,   Head, Research Wing, BMHRC
                                    Bhopal
Research Fellow:       Mrs. Sneha Chakravarty, Senior Research Fellow, NIREH,  Bhopal

We at NIREH have proposed a project to assess damages caused in lungs due to various environmental factors and particularly by Methyl isocyanate gas (MIC) worst industrial disaster to affect any population. Recent reports have suggested a considerable rise in respiratory disorders caused by exposure to pollution. This has led to an exponential increase in cases of asthma, chronic and acute bronchitis allergies and lung inflammation.

Many of the cases of chronic inflammation of lung have progressed to lung cancer with time. Most of these inflammatory states are progressive and severe if not treated. Hence it becomes necessary to assess the extent of damage and take measure for curing the disease. There are group of markers which if estimated can be probable signs of any increase in levels/presence of the disease. These markers are hallmark for very early diagnosis of interstitial lung fibrosis, lung cancer and other lung disorders, when there are apparently no clinical signs for the onset of any serious complications.

The initial cohort identified by regular lab investigations and diagnosis by expert physician would be used for analyzing the levels of biomarkers. Similar lines would be taken for identification of designated cohort of population for MIC affected cases.

            The initial part of the study would be to screen patients based on preliminary investigations. A complete study of all parameters (clinical and physiological) would be carried out by a group of medical experts. Clinical diagnosis of each patient will be confirmed based on this analysis and lung function tests. An initial round of screening of biochemical markers will be carried out. Any increase observed in patients from standard values will be suggestive of some sort of ailment of lung e.g. emphysema, inflammation or lung cancer. A cohort of population can be identified based on the results of the markers which carry definite signs of diseased lungs.

A second state of biomarkers used is more specific for respective lung disease. They would be used for a detailed investigation of these patients. These markers belong to various signaling pathways and genetic markers. They show significance rise in a particular case of lung disease. A third line of analysis of the biochemical markers used will confirm the establishment of lung cancer in cases of patients with chronic inflammation of lungs. The set of markers are specific for cases of lung cancer. Their presence confirms the lung cancer or a relapse of the disease. A systematic approach taken will help prevent and treat many patients who otherwise are not diagnosed. Insight into patient’s medical history becomes very important. It will highlight the number of MIC affected patients who suffered from chronic inflammation in past and have succumbed to the disease or cases where some sure was seen. Similarly figures from parallel set of population not affected from MIC and yet showing onset of cancer will open new doors for the role of environmental pollutants in air.  Further rigorous analysis might help to determine other similar factors which might be potential hazards present in our environment

4.    Title of the project: “Long Term Effect of Toxic gas (MIC) on Ocular Health”

Investigator:-             Dr. R.K. Gupta, Consultant, NIREH, Bhopal

Co investigator:         Dr. Mrs. Saroj Gupta, Associate Professor, People’s Medical College,  Bhopal
                                    Dr. N. Banerjee, Head, NIREH, Bhopal
                                    Dr. Mrs. Kavita Kumar,  Associate Professor of Ophthalmology, Gandhi Medical College, Bhopal
                                    Dr. Brajendra Mishra, Consultant, NIREH, Bhopal

SYNOPSIS OF THE RESEARCH PROJECT

Purpose of this research project is  to study the long term effect of toxic gas (MIC) on ocular health.  Aims and objectives are to evaluate the delayed effects of toxic gas on ocular health .To study the extent of severity of ocular morbidity and to compare it with past prevalence. To detect any new cases of ocular morbidity due to chronic use of drugs. In depth study of lens proteins and ocular surface disorders by impression cytology technique.  Cases will be selected from the registered cohort of 80021 gas affected population and controls will be taken from the registered control cohort of 15931. Patients with ocular symptoms like burning, watering, irritation, redness diminution of vision etc. will be referred to eye clinic at NIREH by the Research officers and Field assistants. These Patients will undergo comprehensive ocular examination by the eye specialist. For in depth study of ocular surface disorders, impression cytology of conjunctiva will be done. It is a simple technique to measure the Goblet cell density and to study the conjunctival cell morphology. In patients with cataract, lens protein analysis will be done to find out the higher incidence of presenile cataract in gas affected population.

Any new clinical disease entity due to delayed effect of toxic gas or chronic drug use or any sequele of old ocular morbidity will also be studied. The toxic effect of MIC gas on retina has been documented in previous studies in the form of pigmentary degeneration of macula. Detailed retinal examination will be done to know the delayed effect of toxic gas on retina. Children born to MIC gas exposed mothers will also be examined to detect any congenital malformations.

Results obtained from present study will be compared with the previous studies done on MIC exposed population. Past prevalence of various ocular morbidities like chronic irritative conjunctivitis, conjunctival xerosis, corneal opacity, pterygium cataract etc.will be compared. Thus we will try to understand and analyze whether there is any long term effect of MIC on exposed population.

 
5.    Title of the project: “Comparative evaluation of long term MIC induced effect on gene-expression through micro array technique in affected and non affected population in Bhopal”.

Investigator:             Prof. V.K. Bharadawaj, Consultant, NIREH, Bhopal

Co investigator:  Prof. N. Kapoor, Gandhi Medical College, Bhopal

  Prof. R. Malik, Gandhi Medical College, Bhopal
  Dr. K. Sahu, HSADL, Bhopal
  Dr. R.K. Pandey, J.N. Cancer Hospital, Bhopal

As per comments the study proposal has not been revised, so the details of the research  proposals is not included in this report.

 6.    Future Mental Health Activities:  (October 2011 to August 2012, Draft)

Terms of Reference: The focus of future work will be to provide guidance for carrying out research in NIREH’s focused areas which include mental health. 

Goals (for the first year):

  • Review and critical evaluation of the mental health studies/ reports of 1984-2011;
  • Understanding the mental health needs of the population;
  • Improving the mental health services for the gas disaster survivors;
  • Develop a long term research agenda for NIREH,Bhopal.

Activities  Planned to meet the above goals:

1.    REVIEW of Past MNH work:

    • Contacting all the professionals, NGO’s  for their mental health work;
    • Review of the literature-national and international;
    • Review article  for IJMR;
    • Information for the general public.

2.     Understanding the mental health  ‘needs’ of the population:

  • Analysis of the current pattern of psychiatric problems reaching psychiatric facilities and treatment utilisation data for 2010; 
  • Collection of  patient data from routine psychiatric care from the different psychiatric facilities in Bhopal;
  • Follow up of the psychiatric cases from the ICMR survey records;
  • Screening of general medical clinic attenders for psychiatric problems;
  • General population study by two stage method; (pilot phase: Oct–Nov 2011)
  • Large scale general population epidemiological study(January 2012-   )

3.      Improving the mental health services for the gas disaster survivors:

  • Mental Health Advisory Group
  • Development of mental health care  indicators;
  • Development of information on mental health issues for the general population; (Dec,2011)
  • Development of a  Mental Health Manual for medical officers(Dec2011);
  • Public Mental Health education activities using mass media-traditional, radio, TV, printed press; 
  • Development of a Mental Health Manual for field level staff-Health workers, NGO staff(Dec.2011);
  • Training programmes for different groups of professionals and personnel(Jan 2012-  )
  • Therapeutic trial for the  ‘psychosocial’ treatment of patients with multiple somatic complaints( multi-centric study of comparison of routine care and ‘psychosocial care’ for a period of 3months)(Jan 2012-Dec2012);
  • Periodic meeting with mental health professionals to improve the treatment utilisation and development of services;
  • Assistance to Gas Rahat department to set up the department of psychiatry (with 10 indoor beds) at Kamala Nehru Hospital (as requested by Dr.Dubey).

4.       Develop a long term research agenda for NIREH,Bhopal.

  • Mental Health Team in NIREH;
  • Development of mental health research tools for disaster MNH research;
  • Focussed epidemiological studies; ( specific population groups;
  • Focussed clinical studies;
  • Focussed therapeutic evaluation studies;
  • Training of professionals for National level MNH research and MNH care   programmes for disaster populations.
  • Dissemination of information through publications, seminars etc.

 



AWARENESS ACTIVITIES        Goto Top

a.     World Environment day

World Environment day was celebrated on 5th June 2011 in presence of all the staff and Consultants.  A poster presentation was also done which was observed and appreciated by many distinguished visitors. 

b.      Rashtriya Hindi Diwas

Institute organized  lecture on "Hindi Bhasha Kitni Samarth" on 14th Septemeber, 2011.   Dr. R.C. Sharma, Consultant, NIREH, ICMR was the Chief Guest on the occasion and it was decided to publish a quarterly bulletin of the Institute in Hindi. 

s
Lecture on "Hindi Bhasha Kitni Samarth" during Rashtriya Hindi Diwas on 14th September 2011
s
Staff of NIREH attended lecture on  "Hindi Bhasha Kitni Samarth" during Rashtriya Hindi Diwas

 


OTHER ACTIVITIES        Goto Top

LINKAGES TO OTHER ORGANIZATIONS

  • To develop inter-linking with other medical organizations and NGOs, the Institute has carried out various activities like, data exchange, scientific discussion and strategic meeting.
  • Visited, the Centre for Rehabilitation of physically and mentally handicapped children, Bhopal by Dr. Arun Bhatnagar, and Dr. R.K. Gupta,  Consultant, NIREH along with Dr. N. Banerjee, Head, NIREH.  It was decided that the children in small groups will be sent to Dr. Bhatnagar for clinical examination and further treatment wherever possible.
  • The Institute has also started preparation of a list of children having birth defects. 
  • It was felt that there is great need to address the need of health education among the gas victim patients.  It was discussed the matter with SOCHARA, a Community Health Cell, a professional group in community health and public health.  A meeting was held in presence of Dr. R.S. Murthy, Consultant, NIREH on 9th September, 2011.  The Project Manager of SOCHRA, Mr. Prasanna Saligram was present in the meeting.

ARCHIVE

Since 1985 lot of information related to various research projects have been preserved in an unscientific manner.  In this present form it may not be possible to understand the value of such data.  Therefore, efforts have been made under the supervision of Dr. H.R. Rajmohan, Scientist ‘F’ and OIC, Regional Occupational Health Centre, Bangalore to create archive so that whatever data available at present should be carefully and scientifically preserved so that if necessary more valuable information can be retrieved in future. 

SCIENTIFIC DOCUMENTATION

The Institute has been collecting documents pertaining to scientific publications, data, seminars, workshops on Bhopal Gas Disaster, from Government, NGOs and other organizations.  Abstracts of the collected scientific documents will be prepared which contains scientific all scientific information.

DOCUMENTS PREPARED

The following documents have been prepared till date:

    • Budget proposal of NIREH for the year 2011-12
    • XII the 5 year plan was prepared and submitted
    • Architectural plan of NIREH for construction at Bhouri, Bhopal
    • Standing Finance Committee Memorandum for establishment of NIREH, ICMR, Bhopal
    • Task Force Report
    • Technical Report on Population Based Long Term Epidemiological Studies (1996-2005)
    • Vision Document for NIREH, Bhopal
    • Renovation plan and construction
    • A Brief report on work done by Government of Madhya Pradesh for gas tragedy victims.


BUDGET        Goto Top

SANCTIONED/EXPENDITURE STATEMENT
(FEBRUARY 2011 TO MARCH 2011)

S.No.

Head

Sanctioned

Expenditure

Balance

1

Consolidated Salary

3180052

785563

2394489

2

 

 

 

Contingencies

 

 

 

Recurring Misc.

1000000

117482

882518

T.A. for Meeting etc

500000

0

500000

Total

4680052

903045

3777007

Cheque received on  31-3-11 From I.C.M.R. H.Q.

270000000

 

270000000

Grant Total

274680052

903045

273777007

(APRIL 2011 TO SEPTEMBER 2011)

S.No.

Head

Allotment

Expenditure

Balance

1

Consolidated Salary

10271508

4981791

5289717

2

Fee for consultant

6000000

758291

5241709

3

T.A.For meeting

500000

307788

192212

4

Other Charges

500000

410309

89691

 

Total

17271508

6458179

10813329

 

Capital Work

270000000

33388000

236612000



        Goto TopAnnexure-I
The details of the Committees and the terms of reference are as follows.  The Director General has constituted Committees as a Think Tank to formulate the action plan for guiding the Institute in respect of various research activities to be carried out in near future.  The details of the other terms of reference should mentioned as below;

1.       EMPOWERED COMMITTEE

  1. Terms of reference:
    1. To approve all proposals relating to the establishment of a full fledged research centre under ICMR at Bhopal.
    2. To approve all proposals relating to purchase for the Centre.
    3. To approve proposals relating to the post creation & appointment for the Centre.
    4. To approve decisions relating to suspension or relaxation of GFRs and RRs where deemed necessary.
    5. Any other decision deemed essential for the establishment of the Research Centre in a time bound manner
  1. List of members of the committee
1. 

Secretary, Department of Health Research/Director General, Indian Council of Medical Research, New Delhi

Chairman

2. 

Additional Secretary & Financial Advisor, Ministry of Health and Family Welfare

Member

3. 

Nominee of Secretary, Department of Expenditure (not below the rank of Joint Secretary

Member

4. 

Nominee of Secretary, Department of Personnel and Training (not below the rank of Joint Secretary

Member

5. 

Nominee of Secretary, Department of Chemicals & Petrochemicals

Member

6. 

Nominee of Planning Commission

Member

7. 

Director General Health Services

 

8. 

Financial Advisor, Indian Council of Medical Research, New Delhi

Member

9. 

Divisional Heads of Indian Council of Medical Research, New Delhi

Member

10. 

Senior Deputy Director General (Administration), Indian Council of Medical Research, New Delhi

Member

11. 

Joint Secretary, Department of Health Research

Member-Secretary

 2.       SCIENTIFIC ADVISORY COMMITTEE

     A.   Purpose

The purpose of the Scientific Advisory is to suggest the mechanism of the modalities for establishing the new Institute by providing necessary guidance for the development of scientific programmes keeping in view, the recommendation of Union Cabinet.

    B.   List of members of the committee

1. 

Dr. V.M. Katoch, Secretary, Government of India, Department of Health Research & Director General Indian Council of Medical Research, New Delhi.

Chairman

2. 

Dr. D.K. Behra, Director,  Lala Ram Sarup Institute of Tuberculosis Respiration, Sri Aurobindo Marg, Near Qutab Minar,  New Delhi

Member

3. 

Dr. S. K. Jain, Consultant,   Mool Chand Hospital,
New Delhi

Member

4. 

Dr. V.K. Vijayan,  Former Director, V.P. Chest Institute,  12, Lesly Villas, Karaparamba, Kozhikode.

Member

5. 

Prof. K.K. Talwar, President, National Academy of Medical Sciences, Ansari Nagar, New Delhi.

Member

6. 

Prof. Suneeta Mittal, Head, Deptt. of Obstetrics and Gyanecology,      All India Institute of Medical Sciences, New Delhi

Member

7. 

Prof. L.K. Dhaliwal,  Postgraduate Institute of  Medical Education and Research,  Chandigarh

Member

8. 

Prof. N. K. Mehra,       Prof. and Head,      Deptt. of  Transplant Immunology  and  Immunogenetics, All India Institute of Medical Sciences,       New Delhi

Member

9. 

Dr. Ramachandran, Instt. of Genomics and Integrated Biology, New Delhi

Member

10. 

Dr. H. Sarat Chandra, Prof., Deptt. of Microbiology and Cell Biology,  Indian Institute of Science,   Bangalore.

Member

11. 

Prof. V.K. Paul,   All India Institute of Medical Sciences, Ansari Nagar,  New Delhi

Member

12. 

Dr. R. Sarin, Director, ACTREC, Tata Memorial Centre, Navi Mumbai, Mumbai

Member

13. 

Prof. Rajesh Kumar,      Postgraduate Institute of Medical and Research, Chandigarh

Member

14. 

Prof. I.C. Tiwari, H-204, B.D.A., Flat,Behind  Ayushman Hospital, Shahpura, Sector 6, Bhopal.

Member

15. 

Dr. P.S.S. Sunder Rao,  80, Gubby Cross, Kuvempu Ley out, Kothanour, Bangalore.

Member

16. 

Dr. Padam Singh, EPOS Health (India) Pvt. Ltd., 445 Udyog Vihar, Phase-III, Gurgaon.-122016 (Haryana)

Member

17. 

Lt. Gen. Raghunath,  Principal Executive, Sir Dorabji Tata Centre for Research in Tropical Diseases Innovation Centre, Indian Institute of Science Campus, Bangalore

Member

18. 

Dr. R.S. Murthy, Prof. of  Psychiatry,    Association for Mentally Challenged,  Hosur Road, Near Kidwai Hospital,  Dharmaram College, Bangalore

Member

19. 

Dr. B. Kumar,  Ex PGIMER,  Chandigarh

Member

20. 

Dr. S. Ghose,  Dr. R. P. Centre for Ophthalmic Sciences,  All India Institute of Medical Sciences,
New Delhi

Member

21. 

Dr. Sanjay Agarwal,  Prof. and Head,   Deptt. Of Nephrology,    All India Institute of Medical Sciences, New Delhi

Member

22. 

Dr. V.N. Jha, Postgraduate Institute of Medical Education and Research, Chandigarh

Member

23. 

Dr. P.M. Bhargava,   Anveshna,   1-7-24, S.S. Nagar,  Street No.8,   Habisguda,    Hyderabad

Member

24. 

Maj. Gen. Dr. S.K. Bansal, NDMA,New Delhi

Member

25. 

Ms. Shalini Prasad,  Joint Secretary, Department of Health Research, Ministry of Health & Family Welfare, Government of India,  Nirman Bhavan,  New Delhi

Member

26. 

Dr.(Mrs.) Sunita Saxena,  Director, National Institute of Pathology, Safdarjang Hospital, New Delhi.

Member

3.       TASK FORCE

A.    Terms of reference

  • To determine and document in a summary form what has been done so far, what is being done and
  • What needs to be done in regard to research, diagnosis  and treatment relating to MIC affected victims 
  • To recommend a procedure for effective and functional inter-linking of the Organization concerned with research, diagnosis and treatment (including epidemiology) relating to MIC affected victims
  • The Task Force will submit it’s report/findings within a period of three months.

B.      List of members of Task Force

1. 

Dr. P.M. Bhargava, Former Director, Centre for Cellular and Molecular Biology, Anveshna,   1-7-24, S.S. Nagar,  Street No.8,   Habisguda,    Hyderabad

Chairman

2. 

Dr. V.K. Vijayan,  Former Director, V.P. Chest Institute,             12, Lesly Villas, Karaparamba, Kozhikode

Member

3. 

Dr. S. K. Jain, Consultant,   Mool Chand Hospital, New Delhi

Member

4. 

Dr. R.S. Murthy, Prof. of  Psychiatry,    Association for Mentally Challenged,  Hosur Road, Near Kidwai Hospital,  Dharmaram College, Bangalore

Member

5. 

Prof. I.C. Tiwari, H-204, B.D.A., Flat,Behind  Ayushman Hospital, Shahpura, Sector 6, Bhopal

Member

6. 

Prof. N.P. Misra, Former Prof. & Head, Department of Medicine, Civil Lines, Bhopal

Member

7. 

Prof. Yogesh Sharma,  Bhopal

Member

8. 

Brig. (Dr.) K.K. Maudar, Director, Bhopal Memorial Hospital, Karond, Bhopal

Member

9. 

Dr. K.K. Dubey, Director, Kamla Nehru Hospital, Bhopal

Member

10. 

Dr. C.C. Chaubal, Bhopal

Member

11. 

Dr. Shyam Agarwal, Bhopal

Member

12. 

Dr. Deepak Mehta, Bhopal

Member

13. 

Dr. C.Satyamala, New Delhi

Member

14. 

Director, AIIMS, New Delhi

Member

15. 

Dr N. Banerjee, Head, National Institute for Research in Environmental Health, Bhopal

Member

16. 

Dr. Bela Shah, Head, Division of NCD, ICMR, New Delhi

Member

17. 

Dr. D.K. Shukla, Scientist ‘F’, NCD Division, ICMR, New Delhi

Member

4.       EXPERTS  COMMITTEE FOR FINALIZING NUMBER AND KIND OF ITEMS AND SPECIFICATIONS OF LABORATORY AND OFFICE FURNITURE.

List of members of the committee

1. 

Prof. N. K. Mehra, Department of Immunology and Immunogenetics, AIIMS, New Delhi

Chairman

2. 

Dr. V.K. Vijayan,  Former Director, V.P. Chest Institute,             12, Lesly Villas, Karaparamba, Kozhikode

Member

3. 

Dr. D.K. Shukla, Scientist ‘F’, ICMR, New Delhi

Member

4. 

Dr. R.C. Sharma, Consultant, NIREH, ICMR, New Delhi

Member

5. 

Mr. K.K. Dubey, Director, Kamla Nehru Hospital, Bhopal

Member

6. 

Dr. N. Banerjee, Head, NIREH, Bhopal

Member

7. 

Mr. Neeraj Pandey, Executive Engineer, Capital Project Administration, Bhopal

Special Invitee

8. 

Dr. R.S. Sharma, Scientist, F, ICMR, New Delhi

Member-Secretary

5.       MONITORING COMMITTEE

As per the recommendation of the experts committee under the Chairmanship of Dr. N.K. Mehra has recommended a separate committee to be constituted for monitoring the activities of renovation work.  Accordingly, Director General, ICMR approved the Monitoring Committee.

List of members of the committee

1. 

Prof. N. K. Mehra, Department of Immunology and Immunogenetics, AIIMS, New Delhi

Chairman

2. 

Dr. V.K. Vijayan,  Former Director, V.P. Chest Institute, 12, Lesly Villas, Karaparamba, Kozhikode – 673 010

Member

3. 

Dr. R.C. Sharma, Consultant, NIREH, ICMR, New Delhi

Member

4. 

Dr. R.S. Sharma, Scientist, F, ICMR, New Delhi

Member

5. 

Dr. H.R. Rajmohan, Scientist ‘F”, ROHC, Bangalore

Member

6. 

Mr. K.K. Dubey, Director, Kamla Nehru Hospital, Bhopal

Member

7. 

Dr. N. Banerjee, Head, NIREH, Bhopal

Member

8. 

Mr. Neeraj Pandey, Executive Engineer, Capital Project Administration, Bhopal

Special Invitee

6.       SPECIFICATION COMMITTEE FOR FURNTURE

List of members of the committee

1. 

Prof. N. K. Mehra, Department of Immunology and Immunogenetics, AIIMS, New Delhi

Chairman

2. 

Dr. V.K. Vijayan,  Former Director, V.P. Chest Institute, 12, Lesly Villas, Karaparamba, Kozhikode

Member

3. 

Dr. D. Behra, LRS Institute, New Delhi

Member

4. 

Dr. Sunita Saxena, Director Institute of Pathology, New Delhi

Member

5. 

Dr. Bela Shah, Head, Division of NCD, ICMR, New Delhi

Member

6. 

Dr. R.C. Sharma, Consultant, NIREH, ICMR, New Delhi

Member

7. 

Dr. D.K. Shukla, Scientist ‘F’ ICMR, New Delhi

Member

8. 

Mr. R.K.  Kalidhar, ACO, ICMR, New Delhi

Member

9. 

Dr. R.S. Sharma, Scientist, F, ICMR, New Delhi

Member-Secretary

10. 

Dr. N. Banerjee, Head, NIREH, Bhopal

Special Invitee

11. 

Mr. Neeraj Pandey, Executive Engineer, Capital Project Administration, Bhopal

Special Invitee

 7.       BUILDING ADVISORY COMMITTEE

The committee was constituted for planning of the new Institute building   as well as to advise on the construction and furnishing to be executed by the Project Management Consultant from time to time. 

List of members of the committee


1.

Dr.V.K.Vijayan, Former Director, Vallabhabhai Patel Chest Institute,12, Lesly Villas, Karaparamba,  Kozhikode, Kerala State

Chairman

2

Shri Dines Bleaker, Former Chief Architect, Environmental Planning and Coordination Organization, Bhopal &Advisor to MP Tourism, Bhopal

Member

3

Prof. Anil Kumar Sharma,  Professor, Environmental Engineering, Mauling Azad National Institute of Technology, Bhopal

Member

4

Shri Ahoy Mishra, Indian Engineering Service, Military Engineering Services, Sultana Infantry, Shahajanabad, Bhopal

Member

5

Shri J.K. Sonkar, Superintending Engineer, Electrical and Maintenance, Public Works Department, Government of Madhya Pradesh, Bhopal

Member

6

Shri R.K. Mandloi, Assistant Professor, Mechanical Engineering Department, Maulana Azad National Institute of Technology, Bhopal

Member

7

Shri K.K. Dubey, Director, Kamla Nehru Hospital, Bhopal

Member

8

Shri R.K. Mehra, Addl. Secretary and Chief Engineer, Public Works Department, Government of Madhya Pradesh, Vallabh Bhawan, Bhopal

Member

9

Head, National Institute for Research in Environmental Health, Bhopal

Member- Secretary

10

11

Can opt specialist members  as and when required under two Scientist from concerned discipline as per the need   under  Microbiologist  /Molecular Biologist/  Pathologist/ Informatics/  Public Health

Member

Member

8.       INSPECTION COMMITTEE

As per the request of Executive Engineer, Capital Project Administration, Bhopal an Inspection committee was constituted for examination of the specification of the furniture.  The committee will visit the shortlisted firms after the identification of firms. 

List of members of the committee

1. 

Prof. N. K. Mehra, Department of Immunology and Immunogenetics, AIIMS, New Delhi

Chairman

2. 

Dr.V.K.Vijayan, Former Director, Vallabhabhai Patel Chest Institute,12, Lesly Villas, Karaparamba, Kozhikode, Kerala State

 

Member

3. 

Mr. K.K. Dubey, Director, Kamla Nehru Hospital, Bhopal

Member

4. 

Dr. R.C. Sharma, Consultant (Administration) ICMR, New Delhi

Member

5. 

Dr. H.R.Rajmohan, Scientist-F, Regional Occupational Health Centre, Bangalore

Member

6. 

Dr. DK Shukla, Scientist-F, NCD Division, ICMR, New Delhi

Member

7. 

Dr. RS  Sharma,   Scientist-F, RHN  Division, ICMR, New Delhi

Member

8. 

Sh. AK  Srivastav, Executive Engineer, ICMR, New Delhi

Member

9. 

Mr. Neeraj Pandey, Executive Engineer, Capital Project Administration, Bhopal

Member

10. 

Sh. R.K Sharma, Sr. Accounts Officer, ICMR, New Delhi

Member

11. 

Smt. Agnes Xalxo, Sr. Administrative Officer, ICMR, New Delhi

Member

12. 

Dr. N. Banerjee , Head, NIREH,   Bhopal       

Member Secretary

ETHICAL COMMITTEE:

 The Ethical Committee was constituted  by DG, ICMR

Annexure-II
The list of staff taken over by ICMR  

Name

Designation

Dr.N.Banerjee

Head of the Office

Dr.Sushil Singh

Research Officer (Computer)

Mrs. Moina Sharma

Assistant Research officer(Stat.)

Dr.B.S.Panwar

Assistant Research officer (Med.)

Dr.U.M.Rao

Assistant Research officer (Med.)

Dr.K.K.Soni

Assistant Research officer (Med.)

Dr.(Mrs.)Ruma Galglekar

Assistant Research officer (Med.)

Mr.Sudhir Shrivastava

Section Officer

Mr.Krishnadas V.K.

Sr. Stenographer

Mr.Mohan Waldhurkar

Accountant

Mr. Sanjay Khare

Statistical Assistant

Mr.Chandra.Shekara Pillai

Data Entry Operator

Mr.Sunil Sharma

Data Entry Operator

Mr.Anand Kori

Data Entry Operator

Mr.Abdlul Mateen Khan

Research Assistant

Mrs.Meena Chaturvedi

Research Assistant

Mrs.Anita Bhavasar

Research Assistant

Mrs.Hemalta Saxena

Research Assistant

Mrs.Seema Khare

Research Assistant

Mrs.Premlata Maheswari

Research Assistant

Mr.Shoieb Khan

Research Assistant

Dr..V.S.Rathore

Research Assistant

Mr.U.S.Chouhan

Research Assistant

Mrs.Renuka  Sen

Research Assistant

Dr..Anita Shukla

Research Assistant

Mrs.Rekha Yadav

Research Assistant

Mrs.Swpna  Azhar

Research Assistant

Mr.D.S.Shukla

Research Assistant

Mrs.Gourie  Shrivastava

Research Assistant

Mr.Rajendra  Shrivastava

Research Assistant

Mr.B.K.Dixit

Research Assistant

Mr.R. Kerala Varma Thampuran

Jr. Stenographer

Mrs.Anita S.Pillai

Lower Division Clerk

Mr.Rajendrakumar Pandey

Data Sorter

Ms. Aysha Khan

Field  Attendant

Mrs.Rukmani Lalwani

Field Attendant

Mehafooz Khan

Field Attendant

Mr.K.D.Sharma

Field Attendant

Mr.M.P.Tiwari

Field Attendant

Mr. Shrikant Mishra

Peon

Mr. Dilip Ugwae

Peon

Mr.Premlal Patwa

Peon

Mr. Abid Hussian

Peon

Mrs. Kusum bai

Sweeper

Annexure-III
  LIST OF EQUIPMENTS    APPROVED BY EQUIPMENT COMMITTEE

S.No.

Molecular Biology Division

1

Thermal Cycler

2

RT PCR*

3

Western blotting unit with film developer*

4

Beckman coulter High speed bench top centrifuge

5

pH System ‘Systronics’ (pH Meter) with electrode and temperature Probe – One No.

6

 DIGITAL BALANCE (gm.)*

7

DIGITAL BALANCE (µm)*

8

 Cryocan (2 in no’s)*

9

  Liquid Nitrogen( LN 2) (2 in no’s)*

10

ELISA reader (Micro plate Reader)

11

Mini Sub Cell GT System with 7x10 CM tray and mini gel caster and combs

12

Power Pack basic power supply 220-240V

13

Spectrophotometer / Nano drop

14

spectrophotometer double beam*

15

Mini Centrifuge ‘REMI’ – One No.

16

Orbital Shakers *

17

Incubators (1 in no)*


S.No.

Immunogenetics and Cytogenetic Division

1

FACS*

2

DNA ELECTROPHORESIS UNIT*

3

pH meter *

4

DIGITAL BALANCE (µm) *

5

ELISA reader*

6

PROTEIN ELECTROPHORESIS-“1D, (4 in no’s)*

7

Normal shakers *

8

Magnetic Stirrer “REMI” with hot Plate with digital Speed – One No. Capacity: 2 Ltr


S.No.

Pathology Division

1

Trinocular Microscope with Camera

2

Olympus Binocular Research Microscope model CX 21

3

Microtome

4

Tissue Processor

5

pH  meter *

6

 DIGITAL BALANCE (gm.) *

7

Blood Gas Analyser


S.No.

Microbiology Division

1

Bio-safety Hoods for DNA Manipulation

2

Incubators (2 in no’s)*

3

Vacuum Pumps *

4

REFERIGERATED CENTRIFUGE *

5

pH meter *

6

DIGITAL BALANCE (gm.) *

7

DIGITAL BALANCE (µm) *

8

Cryocan (3 in no’s)*

9

 Liquid Nitrogen( LN 2) (2 in no’s)*

10

Rotary Shaker ‘REMI’ with Regulator – One No.

11

Water Bath Shaker ‘REMI’ with tray for 12 flasks and additional trays of different size – One No.


S.No.

Biochemistry Division

1

AUTOANALYSER

2

Microfuge

3

SPECTROPHOTOMETER double beam*

4

Clinical Chemical analyser-EM-200

5

Magnetic Stirrer “REMI” with hot Plate with digital Speed – One No. Capacity: 2 Ltr

6

FPLC*

7

REFERIGERATED CENTRIFUGE *

8

pH meter *

9

 DIGITAL BALANCE (gm)*

10

DIGITAL BALANCE (µm) *

11

PROTEIN ELECTROPHORESIS unit*

12

Normal shakers *

13

Revolutionary High Speed Centrifuge ‘REMI’ along with other accessories – One No.

14

Heraeus Primo R Refrigerated Multi-Tasking Table top Centrifuge

15

Haematological Analyser


S.No.

Central Laboratory

1

pH meter *

2

DIGITAL BALANCE (gm)*

3

DIGITAL BALANCE (µm) *

4

-20 0C Deep freezer 

5

-86 0C Deep freezer

6

GEL DOC SYSTEM

7

Ultracentrifuge *

8

Speed vac*

9

Milli-Q Water purification systems

10

Ice Flaking Machine

11

ETO Sterilizer

12

Autoclaving Unit

13

Microfuge


S.No.

PFT LAB/CLINIC

1

Spirometer

2

Pulmonary function test equipment – Complete PFT including F V Loops, lung volumes & diffusing capacity measurements

3

ECG MACHINE

* Not yet procured